childhood cancer

Childhood Cancer

Overview

Childhood cancer is cancer found in young children (from infancy up to age 14) and teenagers (ages 15 to 19). Common types include leukemia, lymphoma, brain tumors, and other solid tumors. These cancers are rare, but many can be treated successfully. Today, over 80% of children and teens with cancer are still alive five years after they are diagnosed.

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What is Childhood Cancer?

Childhood cancer describes a group of cancers that affect children from birth through age 19. It includes pediatric cancers, which are found in infants and younger children up to age 14, and adolescent cancers, which occur in teens between 15 and 19 years old. Each type of childhood cancer is different and may require its treatment plan. Leukemias, brain tumors, and lymphomas are among the most common types seen in this age group.

Around 15,000 children are diagnosed with cancer each year in the U.S. While most kids respond well to treatment, and over 80% live at least five years after diagnosis, the journey doesn’t end there. Childhood cancer and its treatment can affect a child’s growth, development, and long-term health. Ongoing care is needed to monitor and manage any lasting effects, making follow-up support an important part of life after treatment.

Types of Childhood Cancer

The cancers that affect children are often different from those seen in adults. These are the most common types found in kids:

  • Leukemia: Leukemia is the most common cancer in children. It begins in the bone marrow and blood. The two main types in kids are acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). “Acute” means the cancer grows fast, so it needs quick treatment.
  • Brain and Spinal Cord Tumors: These are the second most common cancers in children. There are many kinds, and each needs different treatment. In children, most of these tumors start in the lower parts of the brain, like the cerebellum or brain stem.
  • Neuroblastoma: This cancer starts in immature nerve cells and is most common in babies and very young children under 5. Sometimes it can even be found before birth during a pregnancy scan.
  • Wilms Tumor: Wilms tumor begins in one or both kidneys. It is usually found in children around 3 to 4 years old. A swollen belly or lump is often the first sign. Other symptoms can include fever, pain, nausea, or poor appetite.
  • Lymphoma: Lymphoma starts in the immune system cells called lymphocytes. It usually shows up in the lymph nodes, tonsils, or thymus. It can also spread to the bone marrow or other organs. Signs include weight loss, fever, tiredness, night sweats, or lumps in the neck, underarms, or groin.
  • Rhabdomyosarcoma: Rhabdomyosarcoma (RMS) begins in muscle cells that help the body move. It can grow almost anywhere but often shows up in the head, neck, bladder, reproductive organs, arms, legs, or belly. It may cause a lump, pain, or swelling.
  • Retinoblastoma: This cancer starts in the retina, which is the back part of the eye. It mostly affects babies and children under 6. It’s often noticed when a child’s eye looks unusual—like when the pupil appears white or pink in photos or under light.
  • Osteosarcoma: Osteosarcoma is the most common bone cancer in young people. It usually happens in teens but can affect younger kids too. It often starts in the bones of the arms, legs, or pelvis and may cause pain or swelling.
  • Ewing Sarcoma: This is the second most common type of bone cancer in children and teens. It usually starts in the pelvis, ribs, shoulder blades, or legs. Like osteosarcoma, it can cause pain, swelling, or a lump.

Risk Factors

Doctors know that some inherited conditions (passed down from family) can raise a child’s risk of getting cancer. In the U.S., about 8 to 10 out of every 100 children with cancer have a related genetic condition.

Some genetic conditions linked to higher cancer risk in children include: 

  • Beckwith-Weidemann syndrome
  • Familial adenomatous polyposis (FAP)
  • Fanconi anemia (FA)
  • Li-Fraumeni syndrome
  • Noonan syndrome
  • Von Hippel-Landau disease

It’s good to know that not all children with these conditions will get cancer. Still, if a child has one of these, doctors may suggest regular check-ups or screenings to help find cancer early if it develops.

Symptoms

Signs of childhood cancer can sometimes look like everyday illnesses. Most kids get headaches, tummy aches, or bruises now and then, and these don’t usually mean anything serious. But if a symptom doesn’t go away or keeps getting worse, it’s a good idea to talk to your child’s doctor.

Doctors sometimes use the letters in CHILDCANCER to help remember possible signs of cancer in children:

  • C – Continued, unexplained weight loss
  • H – Headaches, especially with vomiting in the morning
  • I – Increased swelling or ongoing pain in bones, joints, back, or legs
  • L – Lump or swelling in the neck, chest, underarms, belly, or pelvis
  • D – Development of too many bruises, bleeding, or a rash
  • C – Constant or frequent infections
  • A – A white or unusual color seen in the pupil of the eye
  • N – Nausea that doesn’t go away or vomiting without feeling sick
  • C – Constant tiredness or pale skin
  • E – Eye or vision changes that come on suddenly and don’t go away
  • R – Repeated fevers that aren’t caused by common infections

If any of these signs show up and don’t improve, it’s best to have a healthcare provider check your child.

Causes

The exact causes of most childhood cancers are still unknown. Around 8 to 10 percent of childhood cancers are linked to inherited genetic mutations, changes in genes that can be passed down from parents.

Like in adults, cancer in children usually starts when certain genes change, causing cells to grow out of control. In adults, these changes often build up over time from aging or long-term contact with harmful substances. In children, it’s much harder to find environmental causes because cancer is rare at a young age, and it’s difficult to know what they may have been exposed to early in life. 

Researchers are still working to learn more about what might cause cancer in children. 

Diagnosis

Routine blood tests can make your healthcare provider suspect that you may have an acute or chronic form of leukemia and recommend further diagnosis or workup on any leukemia symptoms you may have.

Here are some diagnostic exams and tests
01

Blood Tests

These look for unusual changes in blood cells that might lead to cancer.
02

Imaging Tests

These give doctors pictures of the inside of the body. Examples include CT scans, MRIs, PET scans, and ultrasounds.
03

Biopsy

This involves taking a small sample of tissue or fluid to look at under a microscope and check for cancer cells.
04

Bone Marrow Biopsy and Aspiration

These tests take a sample from the bone marrow (where blood cells are made) to check for signs of cancer.
05

Lumbar Puncture

This test checks the fluid around the brain and spine (called cerebrospinal fluid) for cancer cells or markers.
06

Genetic Tests

These look for changes in genes that are linked to certain childhood cancers and can help guide treatment decisions.

Treatments

There are different ways to treat childhood cancer. The treatment plan depends on the type of cancer and your child’s needs. Common treatments include:

Side Effects of Treatment

Children go through unique challenges during cancer treatment after treatment ends, and even later as survivors. Their treatments are often more intense, and their growing bodies can react differently than adults. Medicines that help adults with symptoms may not always work the same way for kids. The long-term effects of treatment are usually looked at later in the survivorship stage.

Support

Children with cancer and their families need many kinds of support beyond medical treatment. Here are some key types of support:

Emotional Support
Talking to counselors, therapists, or child life specialists can help children express their feelings and cope with fear or stress.
Family Support
Parents and siblings may also need emotional support, including counseling or support groups to help them handle the challenges.
Social Support
Helping children stay connected with friends, classmates, and everyday life can improve their mood and reduce feelings of isolation.
Educational Support
Kids may miss school during treatment. Teachers, tutors, and hospital programs can help them keep up with learning.
Financial Support
Cancer treatment can be expensive. Families may get help from local organizations, government programs, or hospital social workers.
Spiritual Support
Some families find comfort in their faith or through spiritual counseling, especially during difficult times.
Survivorship Support
After treatment, children may need long-term care or regular checkups. Support groups and follow-up programs help them adjust to life after cancer.

Research

Research plays a big role in helping doctors understand, treat, and prevent childhood cancer. It leads to better treatments and gives more children a chance to recover. Here are some important areas of research:

01

Finding Causes

Scientists study genes and possibly environmental factors to learn why cancer happens in children.
02

Developing Better Treatments

Research helps create new treatments that work more effectively and have fewer side effects.
03

Personalized Medicine

Some studies focus on matching treatments to a child’s specific type of cancer or genetic makeup.
04

Improving Early Diagnosis

Researchers look for ways to spot cancer sooner when it's easier to treat.
05

Understanding Long-Term Effects

Studies follow childhood cancer survivors to learn how treatments affect them later in life.
06

Creating Safer Drugs

Researchers work on medicines that target cancer cells without harming healthy ones.
07

Clinical Trials

These are research studies that test new treatments or combinations to see how well they work and how safe they are.

Prevention

Preventing childhood cancer is challenging, as the exact causes aren't always clear. However, there are ways to reduce risk and protect children:

Limiting exposure to harmful chemicals and environmental toxins can reduce the risk of cancer. For example, keeping children away from tobacco smoke or unnecessary radiation helps protect their health.

Encouraging healthy eating, regular physical activity, and proper sleep helps strengthen a child’s immune system and overall health.

Some cancers, like liver cancer, can be linked to infections. Vaccines, like the HPV vaccine, can protect against cancer-causing viruses.

If a child has a family history of cancer, doctors may suggest more frequent checkups or genetic counseling to catch potential risks early.

Children with certain inherited conditions may need regular screenings to spot cancer early before symptoms appear.
Questions to Ask your Healthcare Provider about Childhood Cancer

When your child is diagnosed with cancer, it’s important to gather as much information as possible to make informed decisions about their care. Here are some key questions to ask your healthcare provider to ensure you understand your child's treatment plan and how to support them through this journey:

  • Q1. What type of cancer does my child have?
  • Q2. What are the treatment options available for my child?
  • Q3. What are the possible side effects of the treatment?
  • Q4. How long will the treatment last?
  • Q5. Will my child need to stay in the hospital during treatment?
  • Q6. What can we do to manage pain and discomfort during treatment?
  • Q7. Are there any clinical trials or new treatments available for my child’s cancer?
  • Q8. How can we support my child emotionally during treatment?